Update Billing Account

The Immunology of Endometritis, and the use of Immunomodulators to Improve Pregnancy Success

October 12, 2021

Posted by Dr. Carleigh Fedorka, PhD in Mare Management

Endometritis_Cytology_Ferris Inflammation and/or infection of the endometrium is the leading cause of subfertility in the horse, with persistent breeding-induced endometritis (PBIE) effecting approximately 10-15% of broodmares [1].  The deposition of spermatozoa, seminal plasma, and/or bacteria into the reproductive tract causes an inflammatory response, leading to an activation of the immune system.  This involves an activation of signaling molecules (cytokines), recruitment of immune cells (neutrophils), and eventual release of prostaglandin F2 alpha (PGF2a) from the inflamed endometrium, all of which lead to the eventual expulsion of excess fluid and contaminants [2-10].

Read More

Please Note - photos used in these news articles are available in the public domain, have been purchased through istockphoto or (when referencing breeders or horses) have been submitted to Select Breeders Services Inc. by the breeding farm or horse owner. Photo credit has been provided where applicable. If at anytime you see something that needs to be addressed please feel free to contact us directly.

Sign up for our Email Newsletter

Just enter your email address below!

Flag it
Clicca sulla Bandiera Italiana per visualizzare gli articoli tradotti in italiano.

Flag es
Haga click en la bandera española para ver los artículos traducidos al español.